"While awaiting a coronavirus-specific vaccine, using an existing, available and safe vaccine such as BCG to boost host immunity may represent an important tool against coronavirus.” a study of 178 countries led by Paul Hegarty, a urologist at Mater Hospital in Dublin
"The vaccine stimulates a kind of cellular memory that helps the body fight off new pathogens, what is called “trained immunity.” Mihai Netea, an infectious disease specialist at Radboud University Medical Center in the Netherlands
“It’s the talk of everyone in the medical community here,” a doctor who runs a small clinic in Tokyo, who asked for her name not to be used, told Asia Times. “Honestly, if a patient with a pulmonary disorder, or the other pre-existing conditions that make coronavirus lethal, asked me to vaccinate them with BCG, I would probably do it. I doubt it would be harmful and it might save their life. That’s my personal opinion.”
“Several vaccines including the BCG vaccination have been shown to produce positive ‘heterologous’ or non-specific immune effects leading to improved response against other non-mycobacterial pathogens. This phenomenon was named ‘trained immunity’ and is proposed to be caused by metabolic and epigenetic changes leading to promotion of genetic regions encoding for pro-inflammatory cytokines. BCG vaccination significantly increases the secretion of pro-inflammatory cytokines, specifically IL-1B, which has been shown to play a vital role in antiviral immunity. Additionally, a study in Guinea-Bissau found that children vaccinated with BCG were observed to have a 50% reduction in overall mortality, which was attributed to the vaccine’s effect on reducing respiratory infections and sepsis.” Gonzalo Otazu, an assistant professor of biomedical sciences at the New York Institute of Technology, who studied for his PhD in Japan
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